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Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits

Abstract The high prevalence of insulin resistance and metabolic syndrome in Kuwait increases the risk of type 2 diabetes (T2D) and cardiovascular diseases development. Although the genetic contribution to insulin resistance and metabolic syndrome is established, the role of a disintegrin and metall...

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Principais autores: Hana Drobiova, Ashraf Al Madhoun, Thangavel Alphonse Thanaraj, Arshad Channanath, Prashantha Hebbar, Sardar Sindhu, Rasheed Ahmad, Fahd Al-Mulla, Rabeah Al-Temaimi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-01-01
coleção:Scientific Reports
Assuntos:
ADAM12
Metabolic syndrome
Insulin resistance
Genetic variant
Acesso em linha:https://doi.org/10.1038/s41598-025-34827-1
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