Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits

Abstract The high prevalence of insulin resistance and metabolic syndrome in Kuwait increases the risk of type 2 diabetes (T2D) and cardiovascular diseases development. Although the genetic contribution to insulin resistance and metabolic syndrome is established, the role of a disintegrin and metall...

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Autors principals:	Hana Drobiova, Ashraf Al Madhoun, Thangavel Alphonse Thanaraj, Arshad Channanath, Prashantha Hebbar, Sardar Sindhu, Rasheed Ahmad, Fahd Al-Mulla, Rabeah Al-Temaimi
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-01-01
Col·lecció:	Scientific Reports
Matèries:	ADAM12 Metabolic syndrome Insulin resistance Genetic variant
Accés en línia:	https://doi.org/10.1038/s41598-025-34827-1
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