UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier

Abstract Targeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of mitochondrial pyruvate carrier (MPC), is previously found to inhibit macrophage inflammatory responses independent of M...

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Principais autores:	Linyu Ran, Miao Chen, Jihui Ye, Song Zhang, Zhibing Luo, Tengfei Bai, Chenchen Qian, Quan Zhou, Mengtian Shan, Yong Chu, Joerg Herrmann, Qiang Li, Feilong Wang
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2024-09-01
Serija:	Advanced Science
Teme:	macrophage metabolism mitochondrial pyruvate carrier NLRP3 UK5099
Online dostop:	https://doi.org/10.1002/advs.202307224
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