Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy

Cadmium, a ubiquitous environmental toxicant, disrupts testicular function and fertility. The dipeptidyl peptidase-4 inhibitor linagliptin has shown pronounced anti-inflammatory and anti-apoptotic features; however, its effects against cadmium-evoked testicular impairment have not been examined. Her...

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Autors principals:	Hany H. Arab, Alzahraa A. Elhemiely, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, El-Shaimaa A. Arafa, Ahmed M. Ashour, Ahmed M. Kabel, Ahmed H. Eid
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-07-01
Col·lecció:	Pharmaceuticals
Matèries:	cadmium HMGB1 NLRP3 inflammasome apoptosis autophagy linagliptin
Accés en línia:	https://www.mdpi.com/1424-8247/15/7/852
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