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Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein

ABSTRACT The continuous antigenic shift and drift of influenza A virus (IAV) result in the emergence of novel strains and drug resistance. Accordingly, it is urgent to develop novel antiviral drugs that target host factors. Here, we revealed that tyrosine kinase LYN (Lck/Yes-related novel protein ty...

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Principais autores: Junwen Liu, Jiaxin Huang, Qian Wang, Yanli Wei, Lebin Han, Xin Li, Caoqi Lei, Guohua Deng, Hualan Chen, Qiyun Zhu, Shuai Xu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-05-01
coleção:mBio
Assuntos:
influenza A virus
LYN
tyrosine kinase
phosphorylation
nucleoprotein
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.03759-25
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