RNA modifications can affect RNase H1-mediated PS-ASO activity

Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA, which modulate PS-ASO binding affinities to the R...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Katelyn A. Doxtader Lacy, Xue-hai Liang, Lingdi Zhang, Stanley T. Crooke
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2022-06-01
Цуврал:	Molecular Therapy: Nucleic Acids
Нөхцлүүд:	MT: Oligonucleotides: Therapies and Applications RNase H1 RNA modification antisense oligonucleotide cleavage structure
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2162253122001378
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