RNA modifications can affect RNase H1-mediated PS-ASO activity

Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA, which modulate PS-ASO binding affinities to the R...

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Hlavní autoři:	Katelyn A. Doxtader Lacy, Xue-hai Liang, Lingdi Zhang, Stanley T. Crooke
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2022-06-01
Edice:	Molecular Therapy: Nucleic Acids
Témata:	MT: Oligonucleotides: Therapies and Applications RNase H1 RNA modification antisense oligonucleotide cleavage structure
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2162253122001378
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