RNA modifications can affect RNase H1-mediated PS-ASO activity
Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA, which modulate PS-ASO binding affinities to the R...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
2022-06-01
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| Серія: | Molecular Therapy: Nucleic Acids |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2162253122001378 |
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