RNA modifications can affect RNase H1-mediated PS-ASO activity

Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA, which modulate PS-ASO binding affinities to the R...

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Autors principals:	Katelyn A. Doxtader Lacy, Xue-hai Liang, Lingdi Zhang, Stanley T. Crooke
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-06-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	MT: Oligonucleotides: Therapies and Applications RNase H1 RNA modification antisense oligonucleotide cleavage structure
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253122001378
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