MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2020-06-01
Цуврал:	eLife
Нөхцлүүд:	MARCH5 MCL1 apoptosis NOXA integrated stress response BCLXL
Онлайн хандалт:	https://elifesciences.org/articles/54954
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!