MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	eLife Sciences Publications Ltd 2020-06-01
Σειρά:	eLife
Θέματα:	MARCH5 MCL1 apoptosis NOXA integrated stress response BCLXL
Διαθέσιμο Online:	https://elifesciences.org/articles/54954
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