Código QR (código de barras bidimensional)

MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

תיאור מלא

שמור ב:
Principais autores: Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications Ltd 2020-06-01
סדרה:eLife
נושאים:
MARCH5
MCL1
apoptosis
NOXA
integrated stress response
BCLXL
גישה מקוונת:https://elifesciences.org/articles/54954
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים