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MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

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Principais autores: Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2020-06-01
Serier:eLife
Fag:
MARCH5
MCL1
apoptosis
NOXA
integrated stress response
BCLXL
Online adgang:https://elifesciences.org/articles/54954
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