Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion...

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Detalhes bibliográficos

Principais autores:	Chengcheng Hu, Mi Zhou, Wenzhao Wang, Xianyun Sun, Oded Yarden, Shaojie Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-01-01
coleção:	Frontiers in Microbiology
Assuntos:	azoles stress response sterol 14α-demethylase C-8 sterol isomerase efflux pump sterol intermediate
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fmicb.2018.00009/full
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