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AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated glycolysis

Abstract Objective Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), which is associated with high incidence and mortality. AST-120 is an oral carbonaceous adsorbent that can alleviate kidney damage. This study aimed to explore the effects of AST-120 on renal IRI...

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Principais autores: Jinmeng Zhou, Jinbao Zhang, Feng Xu, Haijin Gao, Lei Wang, Yutong Zhao, Ke Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-08-01
Serier:Molecular Medicine
Fag:
Renal ischemia-reperfusion injury
AST-120
Glycolysis
HK2
Histone lactylation
Online adgang:https://doi.org/10.1186/s10020-024-00902-y
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