Muscone Promotes PINK1/Parkin-Associated Mitophagy to Suppress NLRP3 Inflammasome Activation: Implications for Endotoxemia Therapy

<b>Background</b>: The NLRP3 inflammasome drives pathological inflammation in various diseases. PINK1/Parkin-associated mitophagy serves as a critical negative regulator of NLRP3 activation, yet pharmacological enhancers remain scarce. Muscone, a natural macrocyclic ketone with blood–brain barrier p...

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Autori principali:	Ziwei Yan, Minrui Li, Dan Li, Wentian Hua, Haoxue Cao, Yufei Li, Li Che, Xiyi Chen, Zhicheng Lai, Yi Wang, Guofang Shen, Jing Qian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-05-01
Serie:	Pharmaceuticals
Soggetti:	muscone NLRP3 inflammasome PINK1/Parkin-associated mitophagy mitochondrial quality control macrophages endotoxemia
Accesso online:	https://www.mdpi.com/1424-8247/19/6/816
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