Muscone Promotes PINK1/Parkin-Associated Mitophagy to Suppress NLRP3 Inflammasome Activation: Implications for Endotoxemia Therapy

<b>Background</b>: The NLRP3 inflammasome drives pathological inflammation in various diseases. PINK1/Parkin-associated mitophagy serves as a critical negative regulator of NLRP3 activation, yet pharmacological enhancers remain scarce. Muscone, a natural macrocyclic ketone with blood–brain barrier p...

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Autores principales:	Ziwei Yan, Minrui Li, Dan Li, Wentian Hua, Haoxue Cao, Yufei Li, Li Che, Xiyi Chen, Zhicheng Lai, Yi Wang, Guofang Shen, Jing Qian
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-05-01
Colección:	Pharmaceuticals
Materias:	muscone NLRP3 inflammasome PINK1/Parkin-associated mitophagy mitochondrial quality control macrophages endotoxemia
Acceso en línea:	https://www.mdpi.com/1424-8247/19/6/816
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