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Local translatome sustains synaptic function in impaired Wallerian degeneration

Abstract After injury, severed axons separated from their somas activate programmed axon degeneration, a conserved pathway to initiate their degeneration within a day. Conversely, severed projections deficient in programmed axon degeneration remain morphologically preserved with functional synapses...

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Principais autores: Maria Paglione, Leonardo Restivo, Sarah Zakhia, Arnau Llobet Rosell, Marco Terenzio, Lukas J Neukomm
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2024-10-01
Serier:EMBO Reports
Fag:
Wallerian Degeneration
Programmed Axon Degeneration
Local mRNA Translation
Synaptic Function
Antennal Grooming Behavior
Online adgang:https://doi.org/10.1038/s44319-024-00301-8
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