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A six-gene expression signature in peripheral blood mononuclear cells effectively diagnoses osteoarthritis

IntroductionOsteoarthritis (OA) is a heterogeneous whole-joint disease that inconveniences more than 500 million people worldwide. Early diagnostic methods for OA remain lacking. Peripheral blood mononuclear cells (PBMCs) are ideal sample sources for the early diagnosis of different diseases. Howeve...

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Principais autores: Dong Yu, Wei Ding, Xiuru Xue, Zheng Zhang, Jinchang Meng, Bin Yang, Chunlin Liang, Guanghui Zhao, Xiangmao Bu, Wei Chen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Medicine
Fag:
osteoarthritis
PBMC
RNA sequencing
diagnostic model
expression signature
Online adgang:https://www.frontiersin.org/articles/10.3389/fmed.2025.1632348/full
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