Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning

Abstract Background Osteoarthritis (OA) is the leading cause of degenerative joint disease, with total joint replacement as the only definitive cure. However, no disease-modifying therapy is currently available. Inflammation and fibrosis in the infrapatellar fat pad (IPFP) contribute to OA onset and...

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Ngā kaituhi matua:	Chao Lin, Yue Wan, Yong Xu, Qingsong Zou, Xiaoxiao Li
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-04-01
Rangatū:	Journal of Orthopaedic Surgery and Research
Ngā marau:	Osteoarthritis Infrapatellar fat pad Synovial macrophages scRNA-seq Machine learning Diagnostic signature
Urunga tuihono:	https://doi.org/10.1186/s13018-025-05793-1
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!