Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection

ABSTRACT Disulfide exchange is underexplored as a mechanism influencing HIV-1 entry. Prior studies demonstrated that redox enzyme inhibition can prevent HIV-1 infection but with limited mechanistic explanation. We hypothesize that ligand-driven rearrangement (“conformational activation”) enables enz...

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Main Authors: Charles G. Ang, Nadia L. Hyatt, Giang Le Minh, Monisha Gupta, Manali Kadam, Philip J. Hogg, Amos B. Smith, Irwin M. Chaiken
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2025-03-01
Series:Journal of Virology
Assuntos:
HIV-1
Env
thioredoxins
allosteric disulfides
virus entry
entry inhibitors
Acceso en liña:https://journals.asm.org/doi/10.1128/jvi.01471-24
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