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Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections. We found that dihydrotanshinone I (DHT) specifically blocked the canoni...

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Sparad:
Huvudupphov: Ziying Wei, Xiaoyan Zhan, Kaixin Ding, Guang Xu, Wei Shi, Lutong Ren, Zhie Fang, Tingting Liu, Xiaorong Hou, Jia Zhao, Hui Li, Jiayi Li, Zhiyong Li, Qiang Li, Li Lin, Yan Yang, Xiaohe Xiao, Zhaofang Bai, Junling Cao
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2021-10-01
Serie:Frontiers in Pharmacology
Ämnen:
dihydrotanshinone I
NLRP3 inflammasome
caspase-1
IL-1β
septic shock
Länkar:https://www.frontiersin.org/articles/10.3389/fphar.2021.750815/full
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