Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

Abstract Background Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to idiosyncratic drug-induced liver injury (IDILI) and hepatocyte apoptosis...

Descrición completa

Detalles Bibliográficos

Principais autores:	Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-02-01
Series:	Cell Communication and Signaling
Assuntos:	Epimedii folium Icariside I Idiosyncratic drug-induced liver injury NLRP3 inflammasome
Acceso en liña:	https://doi.org/10.1186/s12964-020-00647-1
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!