Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Abstract Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying mechanisms are still poorly understood. Method...

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Hlavní autoři:	Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-05-01
Edice:	Cell Communication and Signaling
Témata:	NLRP3 inflammasome Idiosyncratic hepatotoxicity Antidepressant Tricyclic antidepressant Nortriptyline
On-line přístup:	https://doi.org/10.1186/s12964-023-01128-x
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