Deubiquitination-related genes define immune subtypes of colorectal cancer and are associated with prognosis and immunotherapy-related signatures

Abstract Colorectal cancer (CRC) is highly heterogeneous, and the contribution of deubiquitination (DUB) programs to immune context and clinical outcome remains incompletely defined. We integrated transcriptomes from TCGA and GTEx (COAD/READ) with an external GEO cohort (GSE39582) to delineate DUB-a...

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Principais autores:	Yiwei Xu, Zhiyong Mo, Qing Jiang, Jingjing Pan, Qi Xu, Juwen Jia
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Series:	Scientific Reports
Assuntos:	Colorectal cancer Deubiquitination Molecular subtypes Immune microenvironment Immunotherapy Prognostic biomarkers
Acceso en liña:	https://doi.org/10.1038/s41598-026-35271-5
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