Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats

Background: Ivacaftor is a modern drug used in the treatment of cystic fibrosis. It is highly lipophilic and exhibits a strong positive food effect. These characteristics can be potentially connected to a pronounced lymphatic transport after oral administration.Methods: A series of studies was condu...

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Главные авторы:	Jiří Pozniak, Pavel Ryšánek, David Smrčka, Petr Kozlík, Tomáš Křížek, Jaroslava Šmardová, Anežka Nováková, Debanjan Das, Daniel Bobek, Mahak Arora, Jiří Hofmann, Tereza Doušová, Martin Šíma, Ondřej Slanař
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2024-02-01
Серии:	Frontiers in Pharmacology
Предметы:	pharmacokintetics lymphatic transport ivacaftor bioavailability intestinal absorption
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1331637/full
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