Development of Abiraterone Acetate Nanocrystal Tablets to Enhance Oral Bioavailability: Formulation Optimization, Characterization, In Vitro Dissolution and Pharmacokinetic Evaluation

Abiraterone acetate is a prodrug of abiraterone used in combination with prednisone as a standard therapeutic strategy for hormone-resistant prostate cancer (mCRPC). Due to the poor solubility and permeability, the release and absorption of abiraterone acetate are low and reduce its bioavailability....

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Principais autores:	Yuanfen Liu, Yuqi Li, Pengcheng Xu, Yan Shen, Baoqiang Tang, Qiyue Wang
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-05-01
叢編:	Pharmaceutics
主題:	abiraterone acetate nanocrystal poloxamer dissolution oral bioavailability
在線閱讀:	https://www.mdpi.com/1999-4923/14/6/1134
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