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The Development of Super-Saturated Rebamipide Eye Drops for Enhanced Solubility, Stability, Patient Compliance, and Bioavailability

The present study aimed to develop clear aqueous rebamipide (REB) eye drops to enhance solubility, stability, patient compliance, and bioavailability. For the preparation of a super-saturated 1.5% REB solution, the pH-modification method using NaOH and a hydrophilic polymer was employed. Low-viscosi...

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Principais autores: Dong-Jin Jang, Jun Hak Lee, Da Hun Kim, Jin-Woo Kim, Tae-Sung Koo, Kwan Hyung Cho
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-03-01
Serier:Pharmaceutics
Fag:
rebamipide
super-saturated eye drop
physical stability
ophthalmic bioavailability
Online adgang:https://www.mdpi.com/1999-4923/15/3/950
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