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Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin

The objective of this prospective study was to examine the exposure to the main active metabolites of ciprofloxacin in critically ill patients and to examine the factors (demographic, laboratory and genetic) that could potentially affect the drug metabolic conversion of ciprofloxacin. The secondary...

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Principais autores: Martin Šíma, Daniel Bobek, Petra Cihlářová, Pavel Ryšánek, Jaroslava Roušarová, Jan Beroušek, Martin Kuchař, Tomáš Vymazal, Ondřej Slanař
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-08-01
Serier:Pharmaceutics
Fag:
desethylene ciprofloxacin
oxociprofloxacin
formyl ciprofloxacin
population pharmacokinetics
pharmacogenetics
gene polymorphism
Online adgang:https://www.mdpi.com/1999-4923/14/8/1627
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