Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors

Abstract Background Intrinsically disordered protein regions (IDRs) are implicated in diverse cellular processes in eukaryotes and, in these organisms, they cover up to 40% of the proteome. Surprisingly little is known about IDRs in bacterial proteomes. Specifically, a number of questions remain una...

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Autors principals:	Uberto Pozzoli, Diego Forni, Federica Arrigoni, Rachele Cagliani, Luca De Gioia, Manuela Sironi
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-11-01
Col·lecció:	Genome Biology
Matèries:	Mycobacterium tuberculosis Intrinsically disordered protein regions Host–pathogen interaction Evolution Conformational features Bacterial proteomes
Accés en línia:	https://doi.org/10.1186/s13059-025-03854-6
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