Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy

Mineralocorticoid receptor antagonists (MRAs) slow cardiomyopathy in patients with Duchenne muscular dystrophy (DMD) and improve skeletal muscle pathology and function in dystrophic mice. However, glucocorticoids, known antiinflammatory drugs, remain a standard of care for DMD, despite substantial s...

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Hlavní autoři:	Zachary M. Howard, Chetan K. Gomatam, Charles P. Rabolli, Jeovanna Lowe, Arden B. Piepho, Shyam S. Bansal, Federica Accornero, Jill A. Rafael-Fortney
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical investigation 2022-10-01
Edice:	JCI Insight
Témata:	Muscle biology
On-line přístup:	https://doi.org/10.1172/jci.insight.159875
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