Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor

Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical studies in mouse models have demonstrated efficacy...

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Autori principali:	Jeovanna Lowe, Arden B. Piepho, Chetan K. Gomatam, Peyton Debell, Megan N. Ballinger, Jill A. Rafael-Fortney
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-12-01
Serie:	Endocrine and Metabolic Science
Soggetti:	Inflammation Muscular dystrophy mdx Mineralocorticoid receptor Myeloid
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2666396125000524
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