Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Abstract Background Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The pur...

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Hlavní autoři:	Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-09-01
Edice:	Arthritis Research & Therapy
Témata:	Endoplasmic reticulum (ER) stress Osteoarthritis Mouse Medial meniscus destabilisation (DMM) ATF6α Apoptosis
On-line přístup:	http://link.springer.com/article/10.1186/s13075-019-1988-6
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