Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Abstract Background Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The pur...

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Bibliografische Detailangaben

Hauptverfasser:	Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-09-01
Schriftenreihe:	Arthritis Research & Therapy
Schlagworte:	Endoplasmic reticulum (ER) stress Osteoarthritis Mouse Medial meniscus destabilisation (DMM) ATF6α Apoptosis
Online-Zugang:	http://link.springer.com/article/10.1186/s13075-019-1988-6
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