Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.

Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endoplasmic reticulum (ER) stress and activation of the u...

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Bibliografiske detaljer

Principais autores:	Louise H W Kung, M Helen Rajpar, Richard Preziosi, Michael D Briggs, Raymond P Boot-Handford
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2015-01-01
Serier:	PLoS ONE
Online adgang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117016&type=printable
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