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Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers

Co-delivery systems of siRNA and chemotherapeutic drugs have been developed as an attractive strategy to optimize the efficacy of chemotherapy towards cancer cells with multidrug resistance. In these typical systems, siRNAs are usually associated to drugs within a carrier but without covalent intera...

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Principais autores: Florian Gauthier, Jean-Rémi Bertrand, Jean-Jacques Vasseur, Christelle Dupouy, Françoise Debart
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-06-01
Series:Molecules
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Acceso en liña:https://www.mdpi.com/1420-3049/25/11/2714
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