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Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers

Co-delivery systems of siRNA and chemotherapeutic drugs have been developed as an attractive strategy to optimize the efficacy of chemotherapy towards cancer cells with multidrug resistance. In these typical systems, siRNAs are usually associated to drugs within a carrier but without covalent intera...

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Autors principals: Florian Gauthier, Jean-Rémi Bertrand, Jean-Jacques Vasseur, Christelle Dupouy, Françoise Debart
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2020-06-01
Col·lecció:Molecules
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Accés en línia:https://www.mdpi.com/1420-3049/25/11/2714
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