From Powerhouse to Perpetrator—Mitochondria in Health and Disease

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect meta...

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Autors principals:	Nima B. Fakouri, Thomas Lau Hansen, Claus Desler, Sharath Anugula, Lene Juel Rasmussen
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2019-05-01
Col·lecció:	Biology
Matèries:	mitochondria cancer nucleotide metabolism DNA damage NAD<sup>+</sup>
Accés en línia:	https://www.mdpi.com/2079-7737/8/2/35
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