From Powerhouse to Perpetrator—Mitochondria in Health and Disease

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect meta...

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Principais autores:	Nima B. Fakouri, Thomas Lau Hansen, Claus Desler, Sharath Anugula, Lene Juel Rasmussen
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2019-05-01
叢編:	Biology
主題:	mitochondria cancer nucleotide metabolism DNA damage NAD<sup>+</sup>
在線閱讀:	https://www.mdpi.com/2079-7737/8/2/35
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