Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy

Abstract Colonic epithelia can be replaced with small intestinal (SI) epithelia through de-epithelialization of the colon using ethylenediaminetetraacetic acid (EDTA), followed by SI organoid transplantation, to treat short bowel syndrome and intestinal failure. However, the low molecular weight (MW...

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Autores principales:	Yuka Matsumoto, Yuta Murakami, Kazuto Suda, Mirei Takahasi, Kenichiro Nakai, Nozomi Ohta, Shihei Motofuji, Go Miyano, Hiroyuki Koga, Nobutaka Hattori, Kiichiro Tsuchiya, Atsuyuki Yamataka, Tetsuya Nakamura
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-11-01
Colección:	Scientific Reports
Materias:	Chelating agents Intestinal organoids Transplantation Regenerative medicine
Acceso en línea:	https://doi.org/10.1038/s41598-025-24998-2
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