Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy

Abstract Colonic epithelia can be replaced with small intestinal (SI) epithelia through de-epithelialization of the colon using ethylenediaminetetraacetic acid (EDTA), followed by SI organoid transplantation, to treat short bowel syndrome and intestinal failure. However, the low molecular weight (MW...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yuka Matsumoto, Yuta Murakami, Kazuto Suda, Mirei Takahasi, Kenichiro Nakai, Nozomi Ohta, Shihei Motofuji, Go Miyano, Hiroyuki Koga, Nobutaka Hattori, Kiichiro Tsuchiya, Atsuyuki Yamataka, Tetsuya Nakamura
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2025-11-01
Sarja:	Scientific Reports
Aiheet:	Chelating agents Intestinal organoids Transplantation Regenerative medicine
Linkit:	https://doi.org/10.1038/s41598-025-24998-2
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