Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy

Abstract Colonic epithelia can be replaced with small intestinal (SI) epithelia through de-epithelialization of the colon using ethylenediaminetetraacetic acid (EDTA), followed by SI organoid transplantation, to treat short bowel syndrome and intestinal failure. However, the low molecular weight (MW...

Descrición completa

Detalles Bibliográficos

Principais autores:	Yuka Matsumoto, Yuta Murakami, Kazuto Suda, Mirei Takahasi, Kenichiro Nakai, Nozomi Ohta, Shihei Motofuji, Go Miyano, Hiroyuki Koga, Nobutaka Hattori, Kiichiro Tsuchiya, Atsuyuki Yamataka, Tetsuya Nakamura
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-11-01
Series:	Scientific Reports
Assuntos:	Chelating agents Intestinal organoids Transplantation Regenerative medicine
Acceso en liña:	https://doi.org/10.1038/s41598-025-24998-2
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!