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RAPID, SENSITIVE, NEW AND SIMPLE UPLC-MS/MS VALIDATED METHOD WITH CHARGED SURFACE HYBRID COLUMN FOR DETERMINATION OF ANTI DEPRESSION DRUG SERTRALINE IN HUMAN PLASMA AND ITS APPLICATION TO BIOEQUIVALENCE STUDY

Background: A rapid, simple, sensitive, reproducible, and RP-UPLC-MS/MS method was established and bioanalytically validated for determining Anti depression drug sertraline in human plasma.Methods: Sertraline was extracted from human plasma by protein precipitation technique using cooled acetonitril...

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Principais autores: Yasser Elshayep, waheed Salem, Abdelhameed Ismail, Fathy Abd allah
Formato: Artigo
Idioma:Inglês
Publicado em: Assiut University, Faculty of Pharmacy 2025-12-01
coleção:Bulletin of Pharmaceutical Sciences. Assiut University
Assuntos:
Sertraline
anti-depressants
LC MS/MS
Human plasma
Bioanalytical
Acesso em linha:https://bpsa.journals.ekb.eg/article_449717_36a0329a538c845f7c3e1e50a1e8b94b.pdf
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