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Application of an LC–MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study

A sensitive and selective method has been proposed for the simultaneous determination of amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The analytes and their deuterated analogs were quantitatively extrac...

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Principais autores: Jaivik V. Shah, Jignesh M. Parekh, Priyanka A. Shah, Priya V. Shah, Mallika Sanyal, Pranav S. Shrivastav
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-10-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Amlodipine
Valsartan
Hydrochlorothiazide
LC–MS/MS
Polypill
Bioequivalence
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177917300679
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