SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women

A rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method is described for determination of letrozole in human plasma. Following solid phase extraction (SPE) of letrozole and letrozole-d4 on Orochem DVB-LP cartridges, chromatography was performed on A...

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Autores principales:	Pravin G. Vanol, Puran Singhal, Priyanka A. Shah, Jaivik V. Shah, Pranav S. Shrivastav, Mallika Sanyal
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2016-08-01
Colección:	Journal of Pharmaceutical Analysis
Materias:	Letrozole Letrozole-D4 UPLC–MS/MS Solid phase extraction Bioequivalence study
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2095177916300508
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