CXCR5 and TIM-3 expressions define distinct exhausted T cell subsets in experimental cutaneous infection with Leishmania mexicana

T-cell exhaustion is a key stage in chronic infections since it limits immunopathology, but also hinders the elimination of pathogens. Exhausted T (Tex) cells encompass dynamic subsets, including progenitor cells that sustain long-term immunity through their memory/stem like properties, and terminal...

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Principais autores:	Mariana Diupotex, Jaime Zamora-Chimal, Julián A. Gajón, Laura C. Bonifaz, Ingeborg Becker
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2023-08-01
Serija:	Frontiers in Immunology
Teme:	cutaneous leishmaniasis chronic infection PD-1 T-cell exhaustion exhausted subpopulations progenitor exhausted cells
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231836/full
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