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Hematopoietic stem progenitor cells with malignancy‐related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4

Abstract The phenotypic changes in hematopoietic stem progenitor cells (HSPCs) with somatic mutations of malignancy‐related genes in patients with acquired aplastic anemia (AA) are poorly understood. As our initial study showed increased CXCR4 expression on HLA allele‐lacking (HLA[−]) HSPCs that sol...

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Principais autores: Takamasa Katagiri, Jorge Luis Espinoza, Mizuho Uemori, Honoka Ikeda, Kohei Hosokawa, Ken Ishiyama, Takeshi Yoroidaka, Tatsuya Imi, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Hiroyuki Kishi, Yasuhiko Yamamoto, Mahmoud Ibrahim Elbadry, Yoshinori Yoshida, Kazuhisa Chonabayashi, Katsuto Takenaka, Koichi Akashi, Yasuhito Nannya, Seishi Ogawa, Shinji Nakao
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-08-01
Serier:eJHaem
Fag:
acquire aplastic anemia
clonal hematopoiesis
CXCR4
hematopoietic stem progenitor cell (HSPC)
HLA class I allele‐lacking cell
Online adgang:https://doi.org/10.1002/jha2.515
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