SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease

Abstract Background Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have be...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini, Dagmar E. Ehrnhoefer
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2021-07-01
Цуврал:	Molecular Neurodegeneration
Нөхцлүүд:	Lysine methylation Protein methyl transferase Nuclear tau Posttranslational modification
Онлайн хандалт:	https://doi.org/10.1186/s13024-021-00468-x
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!