Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Abstract Insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of Alzheimer disease (AD) and other tauopathies. Recently, prefibrillar, soluble, oligomeric tau intermediates have emerged as relevant pathological tau species; however,...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2020-03-01
Цуврал:	Acta Neuropathologica Communications
Нөхцлүүд:	Tau oligomerization Mitochondrial homeostasis Polymerase beta Oxidative stress Tauopathies
Онлайн хандалт:	http://link.springer.com/article/10.1186/s40478-020-00896-8
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!