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SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease

Abstract Background Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have be...

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Autori principali: Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini, Dagmar E. Ehrnhoefer
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2021-07-01
Serie:Molecular Neurodegeneration
Soggetti:
Lysine methylation
Protein methyl transferase
Nuclear tau
Posttranslational modification
Accesso online:https://doi.org/10.1186/s13024-021-00468-x
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